Our team studies the cellular and network mechanisms underlying epileptic seizure genesis in focal cortical dysplasia (FCD). FCD is a congenital malformation of the brain cortex responsible for 30 per cent of all epilepsies. We use a genetic model of FCD in mice, which replicates most features of the human FCD, including the presence of abnormal neurons, dyslamination of the cortex, spontaneous seizures, clustering of seizures and interictal activity. A wide range of electrophysiological techniques, ranging from single-cell recording in brain slices to long-term multi-channel recordings in freely moving animals is employed. Electrophysiological recording is combined with methods of controlling neural activity such as optogenetics and chemogenetics.
New insights of our team into the principles of the transition to seizure and the mechanisms through which the epileptic brain loses resilience before a seizure have been recently achieved. Moreover, we possess a long track record in the research of high-frequency oscillations in epilepsy. Additionally, we have expertise in mathematical approaches to data analysis and numerical modeling.
Currently, we explore the neuronal network principles underlying seizures. We also study the ultra-slow cycles in seizure risk and search for methods of their prediction. Our ultimate goal is to translate all the observed pathophysiological principles into the development of targeted gene therapy for patients with drug-resistant FCD-related epilepsy.
More information about the research team members, their publications and current grant projects is on the EpiReC website: Experimental Neurophysiology Group | EpiReC
